Eddie Jones made six changes to the Japan side that will face France in Paris on Saturday.
Among the backs, scrumhalf Naoto Saito, who plays for French Top 14 champion Toulouse, center Siosaia Fifita and winger Tomoki Osada come in for Shinobu Fujiwara, Nicholas McCurran and Yoshitaka Yazaki after October's 64-19 drubbing by New Zealand.
In the forwards, flanker Kanji Shimokawa, lock Epineri Uluiviti and hooker Mamoru Harada replace Amato Fakatava, Sanaila Waqa and Atsushi Sakate for Saturday's game at Stade de France.
No. 8 Tevita Tatafu, who also plays club rugby in France, for Bordeaux-Begles, is named on the bench, and experienced flyhalf Harumichi Tatekawa continues to captain the side.
"We've picked our strongest 23 for this game," Jones told reporters.
"We've welcomed back Tevita and Saito from the French league.
"Both are those in are good condition," the former England and Australia coach added.
Midfielder Fifita will be making his first test appearance since last year's Rugby World Cup having recovered from a leg injury.
"It's nice to have Fifita back," Australian Jones said.
"He's come back in really good condition and certainly will add to the team," he added.
After facing France, Japan plays Uruguay on Nov. 16 and England eight days later.
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