Scientists are working on a benchmark for COVID-19 vaccine efficacy that would allow drugmakers to conduct smaller, speedier human trials to get them to market and address a huge global vaccine shortage.
Researchers are trying to determine just what level of COVID-19 antibodies a vaccine must produce to provide protection against the illness. Regulators already use such benchmarks — known as correlates of protection — to evaluate flu vaccines without requiring large, lengthy clinical trials.
"You could use it to predict efficacy from a vaccine, which will be more important as we are less able to conduct placebo-controlled trials," said Stanley Plotkin, inventor of the Rubella vaccine and an expert on correlates of protection.
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