NAGOYA — With long-standing differences still dividing COP10 and the tone of negotiations hardening as the conference entered its final days, delegates and NGOs now believe only strong political leadership at the top will yield results.

Senior ministers, including five heads of state, were due to arrive beginning Tuesday for the remaining three days. The fate of the Nagoya meeting now depends on whether the ministers can take over from the bureaucrats who have been negotiating since Oct. 18 and conclude negotiations on three separate but related issues.

These include a new protocol on access to genetic resources, a detailed strategy to preserve biodiversity in the next decade, and funds for developing countries struggling to cope with biodiversity loss.