A former hospital director and a metropolitan government official on Wednesday denied charges of professional negligence resulting in a female patient's death in February 1999, but two other defendants, both nurses, pleaded guilty in the first hearing of their trial at the Tokyo District Court.

The four face charges including professional negligence, falsifying a report and submitting a report too late following the death of Etsuko Nagai, 58.

She was given a disinfectant intravenously at Tokyo Metropolitan Hiroo Hospital in Shibuya Ward.