Prime Minister Theresa May's plans for Brexit were in disarray late Tuesday, after the House of Commons speaker torpedoed her plan to win Parliament's approval of her twice-defeated deal for leaving the European Union.

After two-and-a-half years of negotiations with the bloc, Brexit remains uncertain — with options including a long postponement, exiting with May's deal, an economically disruptive exit without a deal, or even another EU membership referendum.

Speaker John Bercow blindsided May's office on Monday by ruling the government could not put the same Brexit deal to another vote in parliament unless it was substantially different to those defeated on Jan. 15 and March 12.